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The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

30 Apr 2025

Abstract excerpt

The protein alpha-synuclein (αSyn) plays a pivotal role in the pathogenesis of synucleinopathies, including Parkinson's disease and multiple system atrophy, with growing evidence indicating that lipid dyshomeostasis is a key phenotype in these neurodegenerative disorders. Previously, we identified that αSyn localizes, at least in part, to mitochondria-associated endoplasmic reticulum membranes (MAMs), which are...

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PMID: 40307230
DOI: 10.1038/s41531-025-00960-x

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