Article

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance

2024-06-20

Abstract excerpt

While aggregated alpha-Synuclein (αSyn) is commonly associated with Parkinson’s disease, its physiological function as a membrane-binding protein is poorly understood. Here, we show that endogenous αSyn binds lipid droplets (LDs) in multiple human cell lines and in stem cell-derived dopaminergic neurons. LD-binding encompasses αSyn residues 1-100, which masks their detection by immunofluorescence microscopy, proba...

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Literature Corpus work: 9255e226-a4ab-5048-a8c5-12b8d90dc428
DOI: 10.1101/2024.06.19.599670

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