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Article

β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein.

Nature communications - 9 Oct 2024

Li Xi, Yu Linwei, Liu Xikai, Shi Tianyi, Zhang Yu, Xiao Yushuo, Wang Chen, Song Liangliang, Li Ning, Liu Xinran, Chen Yuchen, Petersen Robert B, Cheng Xiang, Xue Weikang, Yu Yanxun V, Xu Li, Zheng Ling, Chen Hong, Huang Kun

Abstract excerpt

Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase separation (LSPS) to form amyloids, how this process is physiologically-regulated remains unclear. β-synuclein colocalizes with α-synuclein in presynaptic...

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Identifiers

PMID: 39384788
DOI: 10.1038/s41467-024-53086-8
PMCID: PMC11464764

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