Article

Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency

2022-12-01

Abstract excerpt

Dysregulated lipid homeostasis is emerging as a potential cause of neurodegenerative disorders. However, evidence of errors in lipid homeostasis as a pathogenic mechanism of neurodegeneration remains limited. Here, we show that the cerebellar neurodegeneration caused by SNX14 deficiency is associated with lipid metabolism defects. Recent in vitro and in silico studies indicate that SNX14 is an inter-organelle li...

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Literature Corpus work: 71e0676d-155f-512f-b19b-3904ffe67cfc
DOI: 10.1101/2022.11.30.516463

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