Article

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in <i>C. elegans</i>

2021-04-22

Abstract excerpt

<h4>ABSTRACT</h4> The ability of organisms to live long depends largely on the maintenance of proteome stability via proteostatic mechanisms including translational regulation, protein chaperoning and degradation machineries. In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, bu...

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Literature Corpus work: fa0df60b-5e66-544c-bfb1-dfa952a8b5ac
DOI: 10.1101/2021.04.22.440991

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