Article

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

2021-05-07

Abstract excerpt

<title>Abstract</title> <p>The ability of organisms to live long depends largely on the maintenance of proteome stability via proteostatic mechanisms including translational regulation, protein chaperoning and degradation machineries. In several long-lived <italic>Caenorhabditis elegans</italic> strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af5628f8-3f97-5cc0-ac4b-330d7fbfd29f
DOI: 10.21203/rs.3.rs-452997/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegansDOI 10.21203/rs.3.rs-452997/v1Read

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in <i>C. elegans</i>Semantic proximity Read

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageingSemantic proximity Read

Lipid perturbation-activated IRE-1 modulates autophagy and lipolysis during endoplasmic reticulum stressSemantic proximity Read

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegansSemantic proximity Read

Autophagy: A Double-Edged Sword in the Aging of <em>C. elegans</em>Semantic proximity Read

Autophagy: A Double-Edged Sword in the Aging of <em>C. elegans</em>Semantic proximity Read

Hyperactive 20S Proteasome Enhances Proteostasis and ERAD in <i>C. elegans</i> via degradation of Intrinsically Disordered ProteinsSemantic proximity Read

Autophagy links lipid metabolism to longevity in<i>C. elegans</i>Semantic proximity Read

Autophagy-mediated longevity is modulated by lipoprotein biogenesisSemantic proximity Read

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and AgingSemantic proximity Read

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagySemantic proximity Read

Chaperone-mediated autophagy as a modulator of aging and longevitySemantic proximity Read