Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism.

Neurobiology of disease - 1 Sept 2024

Adom M A, Hahn W N, McCaffery T D, Moors T E, Zhang X, Svenningsson P, Selkoe D J, Fanning S, Nuber S

Abstract excerpt

Impaired lipid metabolism is a risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB) and can shift the physiological α-synuclein (αS) tetramer-monomer (T:M) ratio toward aggregation prone monomers. A resultant increase in phospho-serine 129+ αS monomers associating with excess mono- and polyunsaturated fatty acids contributes to the αS aggregation. We previously reported that decreasing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Parkinson Disease

Share to Sex Characteristics

Share to Sterol Esterase

Source

Open in PubMed Open full text

Identifiers

PMID: 38971480
DOI: 10.1016/j.nbd.2024.106593
PMCID: PMC11577057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism.PMID 38971480Read ↗

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial DysfunctionSemantic proximity Read ↗

An <i>N</i> -acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson’s diseaseSemantic proximity Read ↗

The role of lipid metabolism in aging, lifespan regulation, and age‐related diseaseSemantic proximity Read ↗

A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.Semantic proximity Read ↗

Increased lipolysis and altered lipid homeostasis protect γ-synuclein-null mutant mice from diet-induced obesity.Semantic proximity Read ↗

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundanceSemantic proximity Read ↗

Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson’s diseaseSemantic proximity Read ↗

Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.Semantic proximity Read ↗

Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasisSemantic proximity Read ↗

Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic MiceSemantic proximity Read ↗

Application of Caenorhabditis elegans in Lipid Metabolism ResearchSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.