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Article

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.

Nature communications - 18 Apr 2026

Poliezhaieva Tetiana, Li Yuting, Chaudhari Prerana Shrikant, Isildak Ulas, Alonso-Pernas Pol, Valentim Isabela Santos, Su Fengting, Espada Lilia, Bayar Melike, Fu Li, Koeberle Andreas, Dönertaş Handan Melike, Ermolaeva Maria A

Abstract excerpt

Mitochondrial dysfunction is a prominent hallmark of aging contributing to the decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity elicit premature aging, the mechanisms leading to "natural" aging of mitochondria are less clear. Here we use proteomics, lipidomics, genetics and functional tests in wild type Caenorhabditis elegans and long-lived clk-1(qm30) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42000749
DOI: 10.1038/s41467-026-71508-7
PMCID: PMC13091796

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