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C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

20 Mar 2008

Abstract excerpt

Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C. elegans model that makes it possible to monitor, in living animals, the formation of alpha-synuclein inclusions. In worms of old age, inclusions contain aggregated alpha- synuclein, resembling a...

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PMID: 18369446
DOI: 10.1371/journal.pgen.1000027

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