Article

Heterogeneous epigenetic variation converges on splicing dysregulation in opioid addiction

2025-12-29

Abstract excerpt

Disease heterogeneity presents a major challenge for genetic and epigenetic dissection of complex traits. Neuropsychiatric traits, such as opioid use disorder (OUD), arise from diverse genetic and environmental factors that uniquely combine in individuals, complicating efforts to identify causal genes and enhancers. We identified epigenetic variation linked to opioid overdose by profiling H3K27ac in the nucleus ac...

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Literature Corpus work: 7eea5dcb-6879-59d2-9b60-6ba530e35f97
DOI: 10.64898/2025.12.20.25342745

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