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Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

28 Jul 2023

Abstract excerpt

Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation (5mC). DNA hydroxymethylation (5hmC) has been widely understudied. We conducted a multi-omics profiling of OUD in a male cohort, integrating neuronal-specific 5mC and 5hmC as well as gene expression profiles from human postmortem...

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PMID: 37507366
DOI: 10.1038/s41467-023-40285-y

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