Article

Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies

2022-12-22

Abstract excerpt

In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a lifetime struggle to control drug consumption, suggesting that opioids trigger long-lasting brain adaptations, notably through functional genomic and epigenomic me...

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Literature Corpus work: ac5a9427-053d-50e9-8c42-37a208b32100
DOI: 10.1101/2022.12.22.521548

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