Article

Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

2020-09-15

Abstract excerpt

<h4>Background</h4> Prevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opioids and who are diagnosed with OUD remains limited. To address this limitation, RNA-sequencing (...

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Literature Corpus work: 7fe87807-748b-50a0-96e8-c54186f34906
DOI: 10.1101/2020.09.14.296707

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