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Article

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.

Nature neuroscience - 1 Sept 2021

Hartl Christopher L, Ramaswami Gokul, Pembroke William G, Muller Sandrine, Pintacuda Greta, Saha Ashis, Parsana Princy, Battle Alexis, Lage Kasper, Geschwind Daniel H

Abstract excerpt

Gene networks have yielded numerous neurobiological insights, yet an integrated view across brain regions is lacking. We leverage RNA sequencing in 864 samples representing 12 brain regions to robustly identify 12 brain-wide, 50 cross-regional and 114 region-specific coexpression modules. Nearly 40% of genes fall into brain-wide modules, while 25% comprise region-specific modules reflecting regional biology, such...

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Identifiers

PMID: 34294919
DOI: 10.1038/s41593-021-00887-5
PMCID: PMC10263365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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