Article

Integrative transcriptomic analysis identifies long noncoding RNA dysregulation and circadian disruption in reward and executive circuits of opioid use disorder

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Opioid use disorder (OUD) is characterized by compulsive drug seeking and impaired executive control arising from maladaptive plasticity within cortico–striatal circuits. While transcriptomic studies have identified coding gene alterations in the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC), the contribution of the noncoding genome remains poorly defined. Here, we performed...

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Literature Corpus work: 25e05a4d-6ca8-5b93-92da-e1ebacb8165a
DOI: 10.64898/2026.02.14.26346327

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