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Article

Addiction-Associated Genetic Variants Implicate Brain Cell Type- and Region-Specific Cis-Regulatory Elements in Addiction Neurobiology.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Oct 2021

Srinivasan Chaitanya, Phan BaDoi N, Lawler Alyssa J, Ramamurthy Easwaran, Kleyman Michael, Brown Ashley R, Kaplow Irene M, Wirthlin Morgan E, Pfenning Andreas R

Abstract excerpt

Recent large genome-wide association studies have identified multiple confident risk loci linked to addiction-associated behavioral traits. Most genetic variants linked to addiction-associated traits lie in noncoding regions of the genome, likely disrupting cis-regulatory element (CRE) function. CREs tend to be highly cell type-specific and may contribute to the functional development of the neural circuits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Mice, Inbred C57BL

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Identifiers

PMID: 34462306
DOI: 10.1523/JNEUROSCI.2534-20.2021
PMCID: PMC8549541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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