Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and Epigenetic Approaches to Opioid Use Disorder.

Expert reviews in molecular medicine - 25 Sept 2025

Ranadeva Nadeeka Dimuthu, Wijekumar Praba Jalini, Fernando Caroline Anastasia, Jayamaha Akila Randika, Noordeen Nafeesa, Chackrewarthy Sureka, Fernando Neluka

Abstract excerpt

BACKGROUND: Opioid use disorder (OUD) is a major global-scale social issue affecting public health. The high potential for addiction and dependence makes opioid use a significant concern, contributing to substance-related disorders. Both genetic and environmental factors contribute to the predisposition to OUD, with the opioidergic, dopaminergic, and GABAergic systems playing primary roles in itsonset. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenesis, Genetic
Share to DRD1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GABRA2 gene

Share to GABRB3 gene

Share to GABRG2 gene

Share to Genetic Predisposition to Disease

Share to Opioid-Related Disorders

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40993075
DOI: 10.1017/erm.2025.10024
PMCID: PMC12571026

Genes

COMT
DRD1
DRD2
DRD3
DRD4
GABRA2
GABRB3
GABRG2
GAD1
GAD2
OPRD1
OPRK1
OPRL1
OPRM1
PDYN
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and Epigenetic Approaches to Opioid Use Disorder.PMID 40993075Read ↗

Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study.Semantic proximity Read ↗

Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.Semantic proximity Read ↗

Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.Semantic proximity Read ↗

Genetic Variants Linked to Opioid Addiction: A Genome Wide Association StudySemantic proximity Read ↗

Association of OPRM1 Functional Coding Variant With Opioid Use DisorderSemantic proximity Read ↗

Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder.Semantic proximity Read ↗

An emerging multi-omic understanding of the genetics of opioid addictionSemantic proximity Read ↗

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.Semantic proximity Read ↗

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Semantic proximity Read ↗

Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Semantic proximity Read ↗

Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of IranSemantic proximity Read ↗

A brief review of the genetics and pharmacogenetics of opioid use disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.