Article

Profiling Neuronal Methylome and Hydroxymethylome of Opioid Use Disorder in the Human Orbitofrontal Cortex

2022-09-15

Abstract excerpt

Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests that there are epigenetic disturbances in OUD, these studies were limited to DNA methylation (5mC). DNA hydroxymethylation (5hmC) has been understudied in psychiatric disorders and addiction, despite being highly enriched in the brain where it regulates critical functions, including neural plasticity. Here,...

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Literature Corpus work: a3da1111-d977-5055-b4e4-63c6736abf0f
DOI: 10.1101/2022.09.09.22279769

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