Article

Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid dependence

2021-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Opioid dependence is a highly heterogeneous disease driven by a variety of genetic and environmental risk factors which have yet to be fully elucidated. We interrogated the effects of opioid dependence on the brain using ChIP-seq to quantify patterns of H3K27 acetylation in dorsolateral prefrontal cortical neurons isolated from 51 opioid-overdose cases and 51 accidental death controls. Among opi...

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Literature Corpus work: dad2a652-2cfe-57b3-bf24-328c7885778c
DOI: 10.1101/2021.06.15.447736

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