Article

A robust method to estimate regional polygenic correlation identifies heterogeneity in the shared heritability between complex traits

2017-05-29

Abstract excerpt

<h4>Background</h4> Complex traits can share a substantial proportion of their polygenic heritability. However, genome-wide polygenic correlations between pairs of traits can mask heterogeneity in their shared polygenic effects across loci. We propose a novel method (WML-RPC) to evaluate polygenic correlation between two complex traits in small genomic regions using summary association statistics. Our method test...

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Literature Corpus work: 7e5c72ce-6a4f-516f-b011-7f1b0f79a3b6
DOI: 10.1101/143644

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