Article

A scalable method for estimating the regional polygenicity of complex traits

2020-01-16

Abstract excerpt

A key question in human genetics is understanding the proportion of SNPs modulating a particular phenotype or the proportion of susceptibility SNPs for a disease, termed polygenicity . Previous studies have observed that complex traits tend to be highly polygenic, opposing the previous belief that only a handful of SNPs contribute to a trait. Beyond these genome-wide estimates, the distribution of polygenicity ac...

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Literature Corpus work: 27afb902-65c0-52d8-b9a0-7cbc3e94b96f
DOI: 10.1101/2020.01.15.908095

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