Article

Non-parametric polygenic risk prediction using partitioned GWAS summary statistics

2018-07-16

Abstract excerpt

In complex trait genetics, the ability to predict phenotype from genotype is the ultimate measure of our understanding of genetic architecture underlying the heritability of a trait. A complete understanding of the genetic basis of a trait should allow for predictive methods with accuracies approaching the trait’s heritability. The highly polygenic nature of quantitative traits and most common phenotypes has motiv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f1d935a-0b39-5f9a-b59c-efb073458771
DOI: 10.1101/370064

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-parametric polygenic risk prediction using partitioned GWAS summary statisticsDOI 10.1101/370064Read

Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics.Semantic proximity Read

Polygenic Prediction via Bayesian Regression and Continuous Shrinkage PriorsSemantic proximity Read

Improving on polygenic scores across complex traits using select and shrink with summary statisticsSemantic proximity Read

Optimizing and benchmarking polygenic risk scores with GWAS summary statisticsSemantic proximity Read

Contrasting the genetic architecture of 30 complex traits from summary association dataSemantic proximity Read

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statisticsSemantic proximity Read

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics.Semantic proximity Read

A fast and robust Bayesian nonparametric method for prediction of complex traits using summary statistics.Semantic proximity Read

Polygenic scores via penalized regression on summary statisticsSemantic proximity Read

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data.Semantic proximity Read

Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction.Semantic proximity Read

A robust method to estimate regional polygenic correlation under misspecified linkage disequilibrium structure.Semantic proximity Read