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Article

A robust method to estimate regional polygenic correlation under misspecified linkage disequilibrium structure.

Genetic epidemiology - 1 Oct 2018

Paré Guillaume, Mao Shihong, Deng Wei Q

Abstract excerpt

Complex traits can share a substantial proportion of their polygenic heritability. However, genome-wide polygenic correlations between pairs of traits can mask heterogeneity in their shared polygenic effects across loci. We propose a novel method (weighted maximum likelihood-regional polygenic correlation [RPC]) to evaluate polygenic correlation between two complex traits in small genomic regions using summary...

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PMID: 30156736
DOI: 10.1002/gepi.22149

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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