Article

Contrasting the genetic architecture of 30 complex traits from summary association data

2016-01-04

Abstract excerpt

Variance components methods that estimate the aggregate contribution of large sets of variants to the heritability of complex traits have yielded important insights into the disease architecture of common diseases. Here, we introduce new methods that estimate the total variance in trait explained by a single locus in the genome (local heritability) from summary GWAS data while accounting for linkage disequilibrium...

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Literature Corpus work: 7a53fcb3-a379-5d8e-85e6-2cbbc9c02f4f
DOI: 10.1101/035907

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