Article
Non-parametric Polygenic Risk Prediction via Partitioned GWAS Summary Statistics.
American journal of human genetics - 2 Jul 2020
Chun Sung, Imakaev Maxim, Hui Daniel, Patsopoulos Nikolaos A, Neale Benjamin M, Kathiresan Sekar, Stitziel Nathan O, Sunyaev Shamil R
Abstract excerpt
In complex trait genetics, the ability to predict phenotype from genotype is the ultimate measure of our understanding of genetic architecture underlying the heritability of a trait. A complete understanding of the genetic basis of a trait should allow for predictive methods with accuracies approaching the trait's heritability. The highly polygenic nature of quantitative traits and most common phenotypes has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.