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Article

Estimating genetic correlation jointly using individual-level and summary-level GWAS data.

Nature communications - 15 Aug 2026

Zhang Yiliang, Jiang Wei, Shen Jiangnan, Cheng Youshu, Ye Yixuan, Lu Qiongshi, Zhao Hongyu

Abstract excerpt

With increasing access to individual-level data from genome-wide association studies, it is now common for researchers to have individual-level data of some traits, whereas for other traits only publicly released summary statistics are available due to privacy and safety concerns. Current genetic-correlation methods require both traits to be in the same format. When one trait has individual-level data and the...

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Topics

Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Computer Simulation
Models, Genetic
Genetic Risk Score

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Multifactorial Inheritance

Source

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Identifiers

PMID: 42736371
DOI: 10.1038/s41467-026-76693-z
PMCID: PMC13574770

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