Article

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations

2018-12-20

Abstract excerpt

The increasing size and diversity of genome-wide association studies provide an exciting opportunity to study how the genetics of complex traits vary among diverse populations. Here, we introduce covariate-adjusted LD score regression (cov-LDSC), a method to accurately estimate genetic heritability and its enrichment in both homogenous and admixed populations with summary statistics and in-sample LD estimates. In...

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Literature Corpus work: 17b742ad-2ca0-5b9c-99e4-16d28c539de6
DOI: 10.1101/503144

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