Article

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits and implications for the future

2017-08-11

Abstract excerpt

<h4>Summary: </h4> -level statistics from genome-wide association studies are now widely used to estimate heritability and co-heritability of traits using the popular linkage-disequilibrium-score (LD-score) regression method. We develop a likelihood-based approach for analyzing summary-level statistics and external LD information to estimate common variants effect-size distributions, characterized by proportion of...

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Literature Corpus work: 9d1ea68c-1039-59bf-ad1f-6310156c4f79
DOI: 10.1101/175406

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