Article

Genome-wide CRISPR screen reveals Wnt signaling defects regulate lipid accumulation in APOE4 oligodendrocytes

2025-10-16

Abstract excerpt

APOE4 is the largest genetic risk factor for late-onset Alzheimer’s disease, but the cellular mechanisms by which APOE variants influence risk of disease remain incompletely understood. We have previously found that APOE4 expression led to the intracellular accumulation of lipid droplets in oligodendrocytes, causing decreased myelination. However, the mechanisms by which APOE4 alters lipid metabolism are not fully...

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Literature Corpus work: 7e402799-cd04-51da-b71c-1fa378efd23e
DOI: 10.1101/2025.10.16.682845

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Genome-wide CRISPR screen reveals Wnt signaling defects regulate lipid accumulation in APOE4 oligodendrocytesDOI 10.1101/2025.10.16.682845Read

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