Article

NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell Activation

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> X Chromosome Inactivation (XCI) is a female-specific process which balances X-linked gene dosage between sexes. Unstimulated T cells lack cytological enrichment of Xist RNA and heterochromatic modifications on the inactive X chromosome (Xi), and these modifications become enriched at the Xi after cell stimulation. Here, we examined allele-specific gene expression and the epigenomic profiles of...

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Literature Corpus work: 72dae3ed-6a96-526a-80d2-90cd2fccc31e
DOI: 10.1101/2024.02.08.579505

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