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Article

Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.

Stem cell reports - 11 Jan 2022

Aizawa Shiho, Nishimura Ken, Mondejar Gonzalo Seminario, Kumar Arun, Bui Phuong Linh, Tran Yen Thi Hai, Kuno Akihiro, Muratani Masafumi, Kobayashi Shin, Nabekura Tsukasa, Shibuya Akira, Sugihara Eiji, Sato Taka-Aki, Fukuda Aya, Hayashi Yohei, Hisatake Koji

Abstract excerpt

Reprogramming of murine female somatic cells to induced pluripotent stem cells (iPSCs) is accompanied by X chromosome reactivation (XCR), by which the inactive X chromosome (Xi) in female somatic cells becomes reactivated. However, how Xi initiates reactivation during reprogramming remains poorly defined. Here, we used a Sendai virus-based reprogramming system to generate partially reprogrammed iPSCs that appear...

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Identifiers

PMID: 34919813
DOI: 10.1016/j.stemcr.2021.11.008
PMCID: PMC8758948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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