Article
Sex-biased and parental allele-specific gene regulation by KDM6A.
Biology of sex differences - 23 Jul 2022
Ma Wenxiu, Fang He, Pease Nicolas, Filippova Galina N, Disteche Christine M, Berletch Joel B
Abstract excerpt
BACKGROUND: KDM6A is a demethylase encoded by a gene with female-biased expression due to escape from X inactivation. Its main role is to facilitate gene expression through removal of the repressive H3K27me3 mark, with evidence of some additional histone demethylase-independent functions. KDM6A mutations have been implicated in congenital disorders such as Kabuki Syndrome, as well as in sex differences in cancer....
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