Article

From Hi-C Contact Map to Three-dimensional Organization of Interphase Human Chromosomes

2020-05-22

Abstract excerpt

The probability of two loci, separated by a certain genome length, being in contact can be inferred using the Chromosome Conformation Capture (3C) method and related Hi-C experiments. How to go from the contact map, a matrix listing the mean contact probabilities between a large number of pairs of loci, to an ensemble of three-dimensional structures is an open problem. A solution to this problem, without assuming...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7de04b32-7291-55d5-8d2a-35ffd360c55e
DOI: 10.1101/2020.05.21.109421

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

From Hi-C Contact Map to Three-dimensional Organization of Interphase Human ChromosomesDOI 10.1101/2020.05.21.109421Read

Minimalistic 3D Chromatin Models: Sparse Interactions in Single Cells Drive the Chromatin Fold and Form Many-Body UnitsSemantic proximity Read

Conformational Heterogeneity in Human Interphase Chromosome Organization Reconciles the FISH and Hi-C ParadoxSemantic proximity Read

Exploring Chromosomal Structural Heterogeneity Across Multiple Cell LinesSemantic proximity Read

Interphase Human Chromosome Exhibits Out of Equilibrium Glassy DynamicsSemantic proximity Read

A Transferable Model For Chromosome ArchitectureSemantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

Architecture of human interphase chromosome determines the spatiotemporal dynamics of chromatin lociSemantic proximity Read

Comparison of the 3D organization of sperm and fibroblast genomes using the Hi-C approachSemantic proximity Read

Heterogeneous interactions and polymer entropy decide organization and dynamics of chromatin domainsSemantic proximity Read

Chromatin structure from high resolution microscopy: scaling laws and microphase separationSemantic proximity Read

Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organizationSemantic proximity Read

Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin foldingSemantic proximity Read