Article

Conformational Heterogeneity in Human Interphase Chromosome Organization Reconciles the FISH and Hi-C Paradox

2019-04-21

Abstract excerpt

Hi-C experiments are used to infer the contact probabilities between loci separated by varying genome lengths. Contact probability should decrease as the spatial distance between two loci increases. However, studies comparing Hi-C and FISH data show that in some cases the distance between one pair of loci, with larger Hi-C readout, is paradoxically larger compared to another pair with a smaller value of the contac...

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Literature Corpus work: 2b2c1ab7-10eb-57b7-956d-bc83d10861c9
DOI: 10.1101/615120

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