Article

Architecture of human interphase chromosome determines the spatiotemporal dynamics of chromatin loci

2017-11-22

Abstract excerpt

By incorporating the information of human chromosome inferred from Hi-C experiments into a heteropolymer model of chromatin chain, we generate a conformational ensemble to investigate its spatiotemporal dynamics. The heterogeneous loci interactions result in hierarchical organization of chromatin chain, which obeys compact space-filling (SF) statistics at intermediate length scale. Remarkably, the higher order arc...

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Literature Corpus work: b42c41e8-e7c1-58ed-84ab-c5a2ac59730a
DOI: 10.1101/223669

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