Article

Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling

2025-07-18

Abstract excerpt

YAP/TAZ signaling is required for initiation of lung alveolar repair, yet previous studies in idiopathic pulmonary fibrosis (IPF) predicted increased YAP/TAZ signaling in alveolar epithelial cells (AECs). We investigated whether persistent YAP/TAZ AEC signaling contributes to failed epithelial repair and persistent fibrotic remodeling. In IPF lungs, we identified increased YAP + /TAZ + AECs and increased express...

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Identifiers and source

Literature Corpus work: 7dd87559-fe18-58d2-ab86-196b9f1529ad
DOI: 10.1101/2025.07.16.665213

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