Article
Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional.
Nature communications - 27 Jul 2021
Stancil Ian T, Michalski Jacob E, Davis-Hall Duncan, Chu Hong Wei, Park Jin-Ah, Magin Chelsea M, Yang Ivana V, Smith Bradford J, Dobrinskikh Evgenia, Schwartz David A
Abstract excerpt
The airway epithelium serves as the interface between the host and external environment. In many chronic lung diseases, the airway is the site of substantial remodeling after injury. While, idiopathic pulmonary fibrosis (IPF) has traditionally been considered a disease of the alveolus and lung matrix, the dominant environmental (cigarette smoking) and genetic (gain of function MUC5B promoter variant) risk factor...
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