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Article

Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis

11 May 2023

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) consists of fibrotic alveolar remodeling and progressive loss of pulmonary function. Genetic and experimental evidence indicates that chronic alveolar injury and failure to properly repair the respiratory epithelium are intrinsic to IPF pathogenesis. Loss of alveolar type 2 (AT2) stem cells or mutations that either impair their self-renewal and/or impair their differentiation...

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PMID: 37166104
DOI: 10.7554/elife.85092

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