Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of human alveolar epithelial type I cells from pluripotent stem cells

19 Apr 2024

Abstract excerpt

Alveolar epithelial type I cells (AT1s) line the gas exchange barrier of the distal lung and have been historically challenging to isolate or maintain in cell culture. Here, we engineer a human in vitro AT1 model system via directed differentiation of induced pluripotent stem cells (iPSCs). We use primary adult AT1 global transcriptomes to suggest benchmarks and pathways, such as Hippo-LATS-YAP/TAZ signaling,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Hippo pathway signaling and YAP/TAZ
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38642558
DOI: 10.1016/j.stem.2024.03.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of human alveolar epithelial type I cells from pluripotent stem cellsPMID 38642558Read ↗

Generation of human alveolar epithelial type I cells from pluripotent stem cellsSemantic proximity Read ↗

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibitionSemantic proximity Read ↗

Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cellsSemantic proximity Read ↗

Directed Differentiation of Human Pluripotent Stem Cells to Functionally Mature Lung Alveolar Cells.Semantic proximity Read ↗

Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosisSemantic proximity Read ↗

iPSC-derived mesenchymal cells that support alveolar organoid developmentSemantic proximity Read ↗

In vitro generation of human pluripotent stem cell derived lung organoidsSemantic proximity Read ↗

An integrated single-cell atlas of human lung across the lifespanSemantic proximity Read ↗

Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epitheliumSemantic proximity Read ↗

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung diseaseSemantic proximity Read ↗

Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factorsSemantic proximity Read ↗

Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.