Article

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

2024-06-18

Abstract excerpt

Pulmonary fibrosis (PF) is a chronic progressive lung disease histopathologically characterized by fibrotic remodeling and the presence of pathological epithelial and mesenchymal cell populations in the distal lung parenchyma. Within the epithelial compartment, a subset of alveolar type 2 cells (AT2s) enter and persist in an aberrant transitional state. Whether and how these aberrant transitional cells participate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bb874c6-48cf-5f75-852c-75cf7d8facef
DOI: 10.1101/2024.06.17.599351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis ModelingDOI 10.1101/2024.06.17.599351Read

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models.Semantic proximity Read

Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosisSemantic proximity Read

Pathogenic Mechanisms Underlying Idiopathic Pulmonary FibrosisSemantic proximity Read

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosisSemantic proximity Read

Epithelial Cell Dysfunction in Pulmonary Fibrosis: Mechanisms, Interactions, and Emerging Therapeutic TargetsSemantic proximity Read

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read

Anomalous epithelial variations and ectopic inflammatory response in chronic obstructive pulmonary diseaseSemantic proximity Read

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read

PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in miceSemantic proximity Read

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosisSemantic proximity Read