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Article

Regeneration-Associated Transitional State Cells in Pulmonary Fibrosis

17 Jun 2022

Abstract excerpt

Pulmonary fibrosis is a chronic, progressive fibrosing interstitial disease. It is characterized by fibroblast proliferation, myofibroblast activation, and massive extracellular matrix deposition. These processes result in loss of lung parenchyma function. The transdifferentiation of alveolar epithelial type II (AEC2) to alveolar epithelial type I cells (AEC1) plays an important role in the epithelial repair...

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PMID: 35743199
DOI: 10.3390/ijms23126757

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