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Article

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts.

Scientific reports - 14 Feb 2017

Noguchi Satoshi, Saito Akira, Mikami Yu, Urushiyama Hirokazu, Horie Masafumi, Matsuzaki Hirotaka, Takeshima Hideyuki, Makita Kosuke, Miyashita Naoya, Mitani Akihisa, Jo Taisuke, Yamauchi Yasuhiro, Terasaki Yasuhiro, Nagase Takahide

Abstract excerpt

Transcriptional coactivator with PDZ-binding motif (TAZ) regulates a variety of biological processes. Nuclear translocation and activation of TAZ are regulated by multiple mechanisms, including actin cytoskeleton and mechanical forces. TAZ is involved in lung alveolarization during lung development and Taz-heterozygous mice are resistant to bleomycin-induced lung fibrosis. In this study, we explored the roles of...

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Identifiers

PMID: 28195168
DOI: 10.1038/srep42595
PMCID: PMC5307361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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