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Article

Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

1 Jul 2021

Abstract excerpt

Proper lung function relies on the precise balance of specialized epithelial cells that coordinate to maintain homeostasis. Herein, we describe essential roles for the transcriptional regulators YAP/TAZ in maintaining lung epithelial homeostasis, reporting that conditional deletion of Yap and Wwtr1/Taz in the lung epithelium of adult mice results in severe defects, including alveolar disorganization and the...

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PMID: 34260916
DOI: 10.1016/j.celrep.2021.109347

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