Article
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models.
Nature communications - 30 Sept 2025
Hoffman Evan T, Shah Anit, Barboza Willy Roque, Rodriguez Luis R, Dherwani Rachna, Dooley Porter E, Minakin Kasey, Tomer Yaniv, Ayers Lauren J, Jones Dakota, Murthy Aditi, Bennett Adam, Lange Ana N, Bawa Pushpinder S, Wang Feiya, Babu Apoorva, Chavez Katrina, Nakamoto Reilly S, Cooper Charlotte H, Basil Maria C, Raredon Micha Sam Brickman, Kotton Darrell N, Alysandratos Konstantinos-Dionysios, Katzen Jeremy
Abstract excerpt
Pulmonary fibrosis (PF) is a progressive disease histologically defined by pathological fibroblasts and epithelial cells. PF lungs contain alveolar type 2 epithelial cells (AT2s) that acquire an aberrant intermediate state phenotype. However, the direct role of these cells in PF and the signals causing them to arise and persist are not fully known. To address this, we harness the SftpcC121G mouse model, where...
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