Article

E3 Ligase UBR5 HECT domain mutations in lymphoma control maturation of B cells via alternative splicing

2019-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Coordination of a number of molecular mechanisms including transcription, alternative splicing, and class switch recombination are required to facilitate development, activation, and survival of B cells. Disruption of these pathways can result in malignant transformation. Recently, next generation sequencing has identified a number of novel mutations in mantle cell lymphoma (MCL) patients includ...

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Literature Corpus work: 7da67373-8937-51a3-86b9-f6d3fed13ca8
DOI: 10.1101/732180

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