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Article

The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.

Blood - 18 Apr 2013

Meissner Barbara, Kridel Robert, Lim Raymond S, Rogic Sanja, Tse Kane, Scott David W, Moore Richard, Mungall Andy J, Marra Marco A, Connors Joseph M, Steidl Christian, Gascoyne Randy D

Abstract excerpt

We have recently reported the application of RNAseq to mantle cell lymphoma (MCL) transcriptomes revealing recurrent mutations in NOTCH1. Here we describe the targeted resequencing of 18 genes mutated in this discovery cohort using a larger cohort of MCL tumors. In addition to frequent mutations in ATM, CCND1, TP53, and NOTCH1, mutations were also observed recurrently in MEF2B, TRAF2, and TET2. Interestingly, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23407552
DOI: 10.1182/blood-2013-01-478834

Genes

UBR5
NOTCH1
ATM
CCND1
TET2
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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