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Article

Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.

International immunology - 1 Aug 1999

Miyazaki T, Kato I, Takeshita S, Karasuyama H, Kudo A

Abstract excerpt

Lambda5 associates with V(pre-B) to form the surrogate light (L) chain. The phenotype of lambda5 knockout mice showed severe impairment of B cell development from pro-B to immature B cell stages. To investigate the function of the surrogate L chain at this stage, we restored expression of lambda5 to lambda5-deficient pro-B cell lines which were established from bone marrow cells of lambda5 knockout mice in the...

Topics

Animals
B-Lymphocytes
Bone Marrow Cells
Cell Differentiation
Cell Line
Gene Expression Regulation
Gene Rearrangement, B-Lymphocyte, Light Chain
Gene Transfer Techniques
Genes, Immunoglobulin
Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Light Chains, Surrogate

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Immunoglobulin lambda-Chains

Interleukin-7

Membrane Glycoproteins

Mice

Source

Identifiers

PMID: 10421777
DOI: 10.1093/intimm/11.8.1195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.PMID 10421777Read ↗

A critical role of lambda 5 protein in B cell development.Semantic proximity Read ↗

The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.Semantic proximity Read ↗

Novel mechanisms control the folding and assembly of λ5/14.1 and VpreB to produce an intact surrogate light chainSemantic proximity Read ↗

Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.Semantic proximity Read ↗

Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.Semantic proximity Read ↗

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.Semantic proximity Read ↗

E3 Ligase UBR5 HECT domain mutations in lymphoma control maturation of B cells via alternative splicingSemantic proximity Read ↗

Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene.Semantic proximity Read ↗

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.Semantic proximity Read ↗

Control of the sizes and contents of precursor B cell repertoires in bone marrow.Semantic proximity Read ↗

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation.Semantic proximity Read ↗

Early B cell development requires mu signaling.Semantic proximity Read ↗

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