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Article

Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.

International immunology - 1 Aug 1999

Miyazaki T, Kato I, Takeshita S, Karasuyama H, Kudo A

Abstract excerpt

Lambda5 associates with V(pre-B) to form the surrogate light (L) chain. The phenotype of lambda5 knockout mice showed severe impairment of B cell development from pro-B to immature B cell stages. To investigate the function of the surrogate L chain at this stage, we restored expression of lambda5 to lambda5-deficient pro-B cell lines which were established from bone marrow cells of lambda5 knockout mice in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10421777
DOI: 10.1093/intimm/11.8.1195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.PMID 10421777Read ↗

A critical role of lambda 5 protein in B cell development.Semantic proximity Read ↗

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Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.Semantic proximity Read ↗

Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.Semantic proximity Read ↗

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.Semantic proximity Read ↗

E3 Ligase UBR5 HECT domain mutations in lymphoma control maturation of B cells via alternative splicingSemantic proximity Read ↗

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Control of the sizes and contents of precursor B cell repertoires in bone marrow.Semantic proximity Read ↗

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation.Semantic proximity Read ↗

Early B cell development requires mu signaling.Semantic proximity Read ↗

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