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Article

Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.

Molecular and cellular biology - 1 Oct 2008

Zhou Anyu, Ou Alexander C, Cho Aeri, Benz Edward J, Huang Shu-Ching

Abstract excerpt

RBM25 has been shown to associate with splicing cofactors SRm160/300 and assembled splicing complexes, but little is known about its splicing regulation. Here, we characterize the functional role of RBM25 in alternative pre-mRNA splicing. Increased RBM25 expression correlated with increased apoptosis and specifically affected the expression of Bcl-x isoforms. RBM25 stimulated proapoptotic Bcl-x(S) 5' splice site...

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Source

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Identifiers

PMID: 18663000
DOI: 10.1128/MCB.00560-08
PMCID: PMC2546994

Genes

RBM25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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