A critical role of lambda 5 protein in B cell development.

doi:10.1016/0092-8674(92)90293-l

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Article

A critical role of lambda 5 protein in B cell development.

Cell - 29 May 1992

Kitamura D, Kudo A, Schaal S, Müller W, Melchers F, Rajewsky K

Abstract excerpt

The lambda 5 gene is a homolog of immunoglobulin J lambda-C lambda genes, expressed specifically in immature B-lineage cells. Lambda 5-encoded molecules form membrane complexes with mu or D mu proteins in association with an additional protein specifically expressed in immature B cells that is encoded by the Vpre-B gene. We have generated mice in which the lambda 5 gene is inactivated by targeted gene disruption...

Topics

Animals
B-Lymphocytes
Base Sequence
Cell Differentiation
Female
Genes, Immunoglobulin
Hematopoietic Stem Cells
Humans
Immunoglobulin Constant Regions
Immunoglobulin Joining Region
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin lambda-Chains

Male

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutagenesis, Insertional

Mutation

Source

Open in PubMed

Identifiers

PMID: 1591779
DOI: 10.1016/0092-8674(92)90293-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1591779-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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