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Article

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.

Molecular cancer research : MCR - 1 Dec 2015

Shearer Robert F, Iconomou Mary, Watts Colin K W, Saunders Darren N

Abstract excerpt

The Ubiquitin-Proteasome System (UPS) is an important regulator of cell signaling and proteostasis, which are essential to a variety of cellular processes. The UPS is disrupted in many diseases including cancer, and targeting the UPS for cancer therapy is gaining wide interest. E3 ubiquitin ligases occupy a key position in the hierarchical UPS enzymatic cascade, largely responsible for determining substrate...

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Source

Identifiers

PMID: 26464214
DOI: 10.1158/1541-7786.MCR-15-0383

Genes

UBR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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